Click Chemistry-Based Synthesis of New 1-formyl-naphthalen-2-yloxymethyl-1,2,3-triazoles, Anticancer Screening and 2D-NMR Studies

A series of 10 various 2-[5-(1-formyl-naphthalen-2-yloxymethyl)-[1,2,3]triazole-1-yl]-substituted phenyl acetamides (5a-5j) were synthesized through copper(I)-catalyzed 1,3-dipolar cycloaddition reaction 2-(prop-2-ynyloxy)naphthalene-1-carbaldehyde (2) and different 2-azido-N-phenylacetamide derivatives (4) under the assorted click chemistry pathway. Its specific biocompatibility to solidify more effectual lead discovery procedures in medicinal has its own space anticancer drugs module. The structural compatibility was studied by HMBC APT type NMR techniques. In vitro, anticytotoxic evaluation indicated that some molecules exhibited potent inhibitory activities cancer cell lines. It been found out screened molecules, 5a 5h demonstrated good cytotoxic potential against CNS, Melanoma, Breast panel. Derivatives 5e 5i, bearing 4-fluoro 4-bromo groups, respectively, average Ovarian, Renal cancer.